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Protein C deficiency (3 common questions in part- 1 exam)

What is the function of protein C?

Inactivation of factors Va and VIIIa

What is the pathological process most likely responsible for increased propensity to clot in a patient diagnosed with protein C deficiency?

Reduced degradation of factors Va and VIIIa

What is the best test to detect protein-C deficiency?

Copperhead snake venom assay

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